主要研究方向：
DNA存儲和計算、生物信息和DNA測序技術等
研究成果概況：
張成現為beat365官方网站，副研究員，博士生導師。主要圍繞生物計算和分子先進制造領域：DNA分子信息處理技術開展研究。以第一或通訊作者身份在Nature，Nature Communications，Science Advances，JACS，Angew. Chem. Int. Ed.，IEEE TNB，中國科學，科學通報等期刊發表論文40餘篇。作為主持人承擔國家省部級項目多個，包括：國家重點研發計劃項目、軍委信息裝備專項、重點研發“政府間”合作專項、國家自然科學基金、教育部聯合基金和北京市聯合專項等。先後獲教育部自然科學獎一等獎（2012）/二等獎（2023）；入選中科院創新交叉團隊（2020），及中國智能計算科技創新人物（2022）。擔任中國計算機，自動化，人工智能等多個學會的生物信息專委會委員。
代表性論文：（*通訊作者）
1.Cheng Zhang*, Ranfeng Wu, Fajia Sun, Yisheng Lin, Yuan Liang, Jiongjiong Teng, Na Liu, Qi Ouyang*, Long Qian*, Hao Yan*. Parallel molecular data storage by printing epigenetic bits on DNA. Nature, 634, 824-832, 2024.
2. Liang Yuan, Qie Yunkai, Jing Yang, Wu Ranfeng, Cui Shuang, Zhao Yuliang, Greg J. Anderson, Guangjun Nie, Suping Li*, Cheng Zhang*. Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction. Nature Communications, 14, 4898, 2023.
3. Jing Yang, Yuan Liang, Xiang Li, Yongpeng Zhang, Long Qian*, Yonggang Ke*, Cheng Zhang*, Spatially Programmable Enzymatic Nanorobot Arm to Modulate Anisotropic Gold Nanoparticle Assembly. Angewandte Chemie International Edition, 62, e202308797, 2023.
4. Cheng Zhang*, Xueying Ma, Xuedong Zheng, Yonggang Ke, Kuiting Chen, Dongsheng Liu, Zuhong Lu, Jing Yang*, Hao Yan*, Programmable Allosteric DNA Regulations for Molecular Networks and Nanomachines. Science advances, 8, eabl4589, 2022.
5. Cheng Zhang*, Zhiyu Wang, Yan Liu, Jing Yang, Xinxin Zhang, Linqiang Pan, Yonggang Ke*, Hao Yan*. Nicking Assisted Reactant Recycle to Implement Entropy-Driven DNA Circuit. J. Am. Chem. Soc., 141, 17189-17197, 2019.
6. Ranfeng Wu, Yongpeng Zhang, Jiongjiong Teng, Qiang Zhang, Cheng Zhang*. Molecular Circuit-Controlled Nanoparticle Folders for Programmable DNA Information Access. ACS nano, 19(19): 6918-6928, 2025.
7. Zhang Yongpeng, Chen Yiming, Liu Xuan, Ling Qian, Wu Ranfeng, Yang Jing*, Cheng Zhang*, Programmable Primer Switching for Regulating Enzymatic DNA Circuits. ACS nano, 18, 5089−5100, 2024.
8. Ranfeng Wu, Yiming Chen, Yongpeng Zhang, Rongming Liu, Qiang Zhang*, Cheng Zhang*, Catalytic Gold Nanoparticle Assembly Programmed by DNAzyme Circuits. Small, 2307107, 2024.
9. Jing Yang, Juan Wang, Xuan Liu, Yiming Chen, Yuan Liang, Qi Wang, Shuoxing Jiang*, Cheng Zhang*. Translocation of Proteins through Solid-State Nanopores Using DNA Polyhedral Carriers. Small, 2303715, 2023.
10. Jing Yang, Ranfeng Wu, Zhiyu Wang, Linqiang Pan, Qiang Zhang, Zuhong Lu*, Cheng Zhang*, Entropy-Driven DNA Logic Circuits Regulated by DNAzyme. Nucleic Acids Research, 46, 8532-8541, 2018.
